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Tuesday, January 17, 2006

SHREWSBURY, N.J. -- In what is believed to be the first time a patient from Connecticut undergoes a rare living-donor nerve transplant, a 21-year-old male from New London received donor nerves from his mother to reverse the paralysis of his right arm on Friday, January 7, 2005. The procedure took place at Monmouth Medical Center, and was performed by a team of medical professionals led by Dr. Andrew Elkwood, M.D. of the Plastic Surgery Center in Shrewsbury, NJ.

The nerve transplant is a complex procedure that utilizes advanced technology in order to reverse many life-altering paralyses. This weekend's surgery was performed on 21-year-old Dylan Brigham's arm, which was left paralyzed from a motorcycle accident in August 2003. As part of the procedure, the medical team surgically removed nerves from his mother's legs, and simultaneously transplanted them into Dylan's arm. The procedure also required the doctors to take nerves from Dylan's own legs and transplant them into his arm.

"Nerve transplants have shown incredible promise in helping once-paralyzed patients regain mobility that surpasses their previous expectations for recovery," said Dr. Andrew Elkwood. "We are extremely pleased with the success of previous living-donor nerve transplants, and anticipate further advancements in medical technology that will continue to help reverse life-altering paralyses caused by accidents, strokes and other medical tragedies."

In May 2004, Dr. Andrew Elkwood performed a father-daughter living-donor nerve transplant, which resulted in the patient gaining full mobility of her once paralyzed arm surpassing all prior prognoses for her recovery. Dr. Elkwood used the same procedure in June 2004 to restore functionality of another patient's paralyzed arm, which was left paralyzed from a car accident nine months prior to the surgery. In addition, Dr. Elkwood made use of cadaverous nerves when he performed the first nerve transplant ever to take place on the East Coast in March 2003, on a patient who was shot in the arm and leg. The patient has since regained near-complete functionality of his once paralyzed arm and leg.

About Dr. Elkwood

Dr. Andrew Elkwood, M.D., is a plastic and reconstructive surgeon who performs unique operations involving nerve rebuilding and complex reconstruction. Dr. Elkwood and his team are among the few doctors in the country to perform operations such as brachial plexus reconstruction, facial reanimation, nerve transplantation, and nerve grafting to preserve erectile function after prostate cancer. Dr. Elkwood is certified by the American Board of Surgery and the American Board of Plastic Surgery in General Surgery and Plastic Surgery. He is also a Fellow of the American College of Surgery (FACS) and a Fellow of the American Society of Aesthetic Plastic Surgery. Dr. Elkwood practices at The Plastic Surgery Center, with offices in NJ and Manhattan. For further information, please visit the Plastic Surgery Center's website at

COPYRIGHT 2005 Business Wire

By middle age, the marks of soft tissue laxity are visible on the face. The corners of the mouth are drooping, the lower eyelids have lengthened, and the malar fat pads are slipping south.

To correct these structural changes and rejuvenate the face, Paul Tessier, M.D., renowned craniofacial surgeon, first described the "midface lift."

However, putting the tissue back where it belonged and holding it there was not an easy matter. Surgeons encountered three problems: difficulty of dissection, difficulty of fixation and unpredictability of results.

Attempts to "improve" on Dr. Tessier's procedure led to a profusion of individualized techniques but only modest gains in ease or predictability. Today, the midface continues to be the most complicated and frustrating operation that many surgeons perform.

Altering midface dynamic

In October 2003, the U.S. Food and Drug Administration (FDA) cleared the Endotine Midface developed by Coapt Systems for subperiosteal midface suspension.

Packaged with disposable insertion tools, the implant is a small, five-tined platform attached to an ultra-thin leash. The tines grip subdermal cheek tissue, spreading tension over a broad area. Once implanted, the L-lactide/glycolide device begins to dissolve as tissues reaffix to the zygoma and maxilla. At five months, only 40 percent of the initial mass remains. At 12 months, the device is completely reabsorbed.

After using the implant in more than 75 patients (about half of them enrolled in clinical trials), we conclude that the Endotine makes fixation easy, fast and adjustable--without the awkward, unpredictable and hazardous placement of sutures. Operating time is markedly reduced by as much as an hour overall. Most importantly, results are predictable and often dramatic, leading to uniformly satisfied patients.

Patient selection

Patient selection is a key factor in good outcomes. The target population is 40- to 60-year-old women and men who have minimal to moderate laxity and good elasticity.

Younger patients get more dramatic results with improvements extending from the eyes to the lower midface and jowl. Benefits to older patients are concentrated in the upper midface. We do not recommend the procedure for patients over the age of 60 because attachment between periosteum and soft tissue is too lax.


Very few patients are familiar with the midface lift.

Some arrive for consultation with a browlift in mind but later opt for a combination of browlift and midface lift. This produces synergistic results that are more dramatic than the midface alone. Other patients seek a "natural" slightly younger look with minimal discomfort and downtime. A third group--generally in their 50s--has already had surgical intervention to the lower face and neck but complains that this did not produce a healthy, rejuvenated appearance.

Overall, the midface is ideal for patients who have been receiving botulinum and dermal filler treatments and are now willing to move on to a procedure that has fewer stigmata and less scarring and potential hairline alterations than a full facelift. We look at the midface as a "transitional" procedure, not as a replacement for the facelift.

Implanting the device

The Endotine maybe inserted through incisions in either the temporal or buccal sulcus areas. The dissection phase of the operation remains largely unchanged, whether using an open or endoscopic approach.

If the Endotine is implanted through the temporal incision, the device is introduced using the insertion tool. If the Endotine is implanted through an oral incision in a retrograde fashion, it helps to first trim the edges of the leash so passage is smoother. The device is then introduced through the mouth, grasped (via temporal incisions) with forceps, and pulled through.

Regardless of point of entry, the device sits over the maxillary antrum, not the zygoma. After the insertion tool is retracted, digital pressure to the exterior of the cheek forces the tines into the periosteum. Tension on the leash completes the engagement process and lifts the periosteum along with attached skin and soft tissue. Surgeons can quickly experiment with vectors and degrees of tautness until the desired aesthetic is achieved. Finally, the leash is sutured to deep temporal fascia, and all incisions are closed.

More dramatic results

Combining the midface with a browlift will produce more elevation and, therefore, more dramatic results. (In fact, overcorrection is now a possibility.) The operation takes about 50 percent longer than a browlift alone.

In the postoperative phase, patients need to be on a soft food diet and warned against heavy lifting or straining. Bruising and edema should resolve within seven to 14 days. The recovery period can be reduced by diligent use of ice compresses for the first 48 hours. Some patients, especially thinner ones, may complain of discomfort upon palpation. However, this has not been a significant issue. Placement of the device is sufficiently distant from the facial nerve branches (frontal, orbital and zygomatic) that nerve damage is unlikely. Depending on the extent of dissection, a rare patient may experience nerve weakness during brow elevation, closure of eyes, or elevation of the corner of the mouth. This is a temporary issue, unrelated to fixation; it should resolve within six weeks.

In the first 75-plus consecutive patients, there have been no complications, no extrusions, no instances when the lift slipped, and no requests for removal of the device.

Benefits of sutureless fixation

The problems with sutures are numerous. It takes time to prepare and place the sutures. They have to be threaded up to the brow like puppet strings. Adjustments to tension or vector are difficult to achieve and time-consuming.

If placed in the wrong position, sutures must be removed and redone. This leads to multiple puncture points, which are vulnerable to infection. Sutures that remain in place may break, entrap nerves, tear through tissue or cause dimpling.

Use of the Endotine Midface eliminates all of these problems. (It is especially helpful in patients who have more tissue mass, such as men.) Achieving symmetry is easy and fast. If necessary, surgeons can go back in and reposition the device or tighten the lift for a period of several weeks after surgery.

In the past, we've experienced redo rates of around 10 percent. The Endotine also eliminates that. There is only one trip to the operating room. Any needed adjustments can be quickly made in the office under a local anesthetic. Finally, because the device is bioabsorbable, there is no need to remove sutures.

The Endotine is the first device specifically designed for subperiosteal midface tissue fixation. It shaves 30 to 60 minutes and a lot of frustration from a standard operation.


The midface lift, when approached through intraoral or temporal incisions and matched to the Endotine, effectively addresses the concerns of middle-aged women and men who want to look rejuvenated in a subtle, natural way with less bruising, swelling and downtime.

Patients who have had a forehead lift in conjunction with the midface suspension appear to be the happiest. Many report favorable comments from friends and family, leading to a high level of satisfaction.

Dr. Berkowitz is a plastic surgeon based in the San Francisco Bay Area. Dr. Beeson has a private practice in Carmel, Ind., where he performs otolaryngology/head, neck and facial . Dr. Moscoe is a plastic surgeon in Austin, Texas.

Disclosure: Drs. Berkowitz, Beeson and Moscoe have served as clinical investigators for Coapt Systems. Dr. Moscoe has no financial interest in the company. As members of the Coapt medical advisory board, Drs. Beeson and Berkowitz have stock option grants.

COPYRIGHT 2005 Advanstar Communications, Inc.